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Welcome to Janssen Immunology Clinical Studies

We are committed to finding new treatment options for patients with immune-mediated inflammatory diseases (IMIDs).

Click on the “View Study” buttons below to view the Clinical Studies information

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APEX
Phase 3b
Evaluate the efficacy and safety of guselkumab in improving the signs and symptoms and inhibiting radiographic progression in participants with active psoriatic arthritis
STAR
Phase 4
Evaluate the efficacy and safety of guselkumab in participants with active psoriatic arthritis axial disease
SOLSTICE
Phase 3b
Evaluate the efficacy and safety of guselkumab treatment in participants with active psoriatic arthritis and inadequate response and/or intolerance to a prior anti-tumor necrosis factor
AFFINITY
Phase 2a
Evaluate the efficacy and safety of guselkumab plus golimumab combination treatment in participants with active psoriatic arthritis and inadequate response to ≤2 prior
anti-tumor necrosis factor therapies compared with guselkumab monotherapy
PSUMMIT-JR
Phase 3
Evaluate the pharmacokinetics and efficacy of ustekinumab and guselkumab in juvenile psoriatic arthritis
UNITED
Phase 3
Collect long-term safety data of subcutaneous ustekinumab in pediatric participants with Crohn’s disease, ulcerative colitis, or psoriatic arthritis
PAMPA
Phase 4
Collaborative study to evaluate whether intervention with guselkumab will prevent the progression of psoriasis to psoriatic arthritis by diminishing musculoskeletal power-doppler ultrasound findings and significantly reduce or prevent the emergence of synovio-enthesial phenotype
SPIREA
Phase 2
Evaluate the efficacy and safety of nipocalimab versus placebo in participants with active idiopathic inflammatory myopathies
JASMINE
Phase 2
Evaluate the efficacy and safety of nipocalimab versus placebo in participants with active systemic lupus erythematosus
THEIA
Phase 2
Evaluate the efficacy and safety of guselkumab compared with placebo, in combination with a 26-week glucocorticoid taper regimen, in adult participants with new-onset or relapsing giant cell arteritis
U-POPS
Phase 1
Evaluate the pharmacokinetics of ustekinumab in juvenile psoriatic arthritis and psoriasis
EVOLUTION
Phase 3
Determine whether switching to a selective interleukin-23 inhibitor (guselkumab) is more effective than switching to a second tumor necrosis factor inhibitor (golimumab) in adult participants with psoriatic arthritis who have an inadequate response to a tumor necrosis factor inhibitor
OTIS
Observational
Monitor planned and unplanned pregnancies exposed to certain medications, to evaluate the possible teratogenic effect of these medications and to follow live born infants for one year after birth
NCT03218488
Observational
Evaluate the
long-term safety of ustekinumab in the treatment of pediatric participants aged 6 years and older with moderate to severe plaque psoriasis
RESTORE-AD
Phase 2a
Evaluate the efficacy, safety, and tolerability of JNJ-67484703 in adult participants with moderate to severe atopic dermatitis
ASTRO
Phase 3
Evaluate the efficacy, including clinical remission, of guselkumab subcutaneous induction compared with placebo in adult participants with moderately to severely active ulcerative colitis
FUZION CD
Phase 3
Evaluate efficacy of guselkumab in fistulizing, perianal Crohn’s disease and assess the overall safety of guselkumab
DUET-UC
Phase 2b
Evaluate efficacy and safety of
JNJ-78934804 compared with guselkumab and golimumab in adult participants with moderately to severely active ulcerative colitis
DUET-CD
Phase 2b
Evaluate the efficacy of JNJ-78934804 compared with guselkumab and golimumab in adult patients with moderately to severely active Crohn’s disease
UNIFI JR
Phase 3
Evaluate the efficacy, safety, and pharmacokinetics of ustekinumab in pediatric participants with moderately to severely active ulcerative colitis
UNITI JR
Phase 3
Evaluate the efficacy, safety, and pharmacokinetics of ustekinumab in pediatric participants with moderately to severely active Crohn’s disease
ENERGY
Phase 2/3
Evaluate the efficacy and safety of nipocalimab compared with placebo for the treatment of adult participants with warm autoimmune hemolytic anemia
VIBRANCE MG
Phase 2/3
Evaluate the pharmacokinetics, pharmacodynamics, safety, and activity of nipocalimab in pediatric participants with generalized myasthenia gravis
VIVACITY MG3
Phase 3
Evaluate the efficacy and safety of nipocalimab compared to placebo in adult participants with generalized myasthenia gravis
ARISE
Phase 2/3
Evaluate the safety and efficacy of nipocalimab versus placebo in delaying relapse in adult participants with chronic inflammatory demyelinating polyneuropathy

Correct as of August 2023

For investigational agents or investigational uses of products, the safety and efficacy have not been determined. There is no guarantee that the investigational agents listed will be filed with and/or approved for marketing by the FDA. For additional information you may visit www.clinicaltrials.gov.